【摘要】 目的 探討丁螺環(huán)酮治療重癥監(jiān)護(hù)室患者焦慮障礙的有效性和安全性。方法 122例重癥監(jiān)護(hù)室焦慮患者作為研究對(duì)象， 采用隨機(jī)數(shù)字表法隨機(jī)分治療組和對(duì)照組， 各61例。治療組給予丁螺環(huán)酮治療， 對(duì)照組給予阿普唑侖治療。治療1周后， 比較兩組患者的焦慮自評(píng)量表（SAS）和焦慮量表（HAMA）評(píng)分， 記錄兩組患者治療過程中的不良反應(yīng)。結(jié)果 治療后治療組SAS、HAMA評(píng)分（28.61±5.56）、（8.15±2.45）分明顯低于治療前的（64.49±7.40）、（30.52±8.56）分， 差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）;對(duì)照組SAS、HAMA評(píng)分（29.05±5.69）、（8.36±2.46）分明顯低于治療前的（64.64±7.25）、（30.13±8.38）分， 差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）;治療后治療組與對(duì)照組HAMA、SAS評(píng)分比較差異無統(tǒng)計(jì)學(xué)意義（P>0.05）;治療組治療總有效率為98.4%， 對(duì)照組治療總有效率為96.7%， 兩組比較差異無統(tǒng)計(jì)學(xué)意義（P>0.05）;治療組不良反應(yīng)發(fā)生率11.48%明顯低于對(duì)照組的44.26%， 差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）;兩組治療前后血尿便常規(guī)、凝血五項(xiàng)及肝腎功能比較差異無統(tǒng)計(jì)學(xué)意義（P>0.05）。結(jié)論 丁螺環(huán)酮對(duì)于治療重癥監(jiān)護(hù)室焦慮障礙的患者是安全的、有效的， 值得臨床推廣。
　　【關(guān)鍵詞】 丁螺環(huán)酮;焦慮癥;重癥監(jiān)護(hù)室
　　DOI：10.14163/j.cnki.11-5547/r.2018.12.003
　　【Abstract】 Objective To investigate the effectiveness and safety of buspirone in the treatment of patients with anxiety in intensive care unit. Methods A total of 122 patients with anxiety in intensive care unit as study subjects were divided by random number table method into treatment group and control group， with 61 cases in each group. The treatment group was treated with buspirone， and the control group was treated with alprazolam. After 1 week of treatment， the self-rating anxiety scale （SAS） and Hamilton depression scale （HAMA） score between the two groups was compared， and the the adverse reactions during treatment was recorded. Results After treatment， the treatment group had obviously lower SAS and HAMA score as （28.61±5.56） and （8.15±2.45） points than （64.49±7.40） and（30.52±8.56） points before treatment， and their difference was statistically significant（P<0.05）. The control group had obviously lower SAS and HAMA score as （29.05±5.69） and （8.36±2.46） points than （64.64±7.25） and （30.13±8.38） points before treatment， and their difference was statistically significant （P<0.05）. After treatment， the treatment group and control group had no statistically significant difference in HAMA and SAS score （P>0.05）. The treatment group had total treatment effective rate as 98.4%， which was 96.7% in the control group， and the difference was not statistically significant （P>0.05）. The treatment group had obviously lower incidence of adverse reactions as 11.48% than 44.26% in the control group， and the difference was statistically significant （P<0.05）. Both groups had no statistically significant difference in hematuria routine， blood coagulation， liver and kidney function before and after treatment （P>0.05）. Conclusion Buspirone is safe and effective in treating patients with anxiety in intensive care unit， and it is worthy of clinical promotion.

相關(guān)熱詞搜索：療效 焦慮 重癥 患者 治療