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坦索羅辛單藥治療后加用索利那新對良性前列腺增生伴膀胱過度活動癥的應(yīng)用價值分析

發(fā)布時間:2018-06-23 來源: 散文精選 點擊:

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  【摘要】 目的 探討坦索羅辛單藥治療后加用索利那新對良性前列腺增生(BPH)伴膀胱過度活動癥(OAB)的應(yīng)用價值。方法 120例良性前列腺增生伴膀胱過度活動癥患者, 隨機分為對照組與觀察組, 每組60例。對照組單用坦索羅辛治療, 觀察組采用坦索羅辛聯(lián)合索利那新治療。比較兩組患者的癥狀改善情況、尿流動力學(xué)參數(shù)改變情況、不良反應(yīng)發(fā)生情況。結(jié)果 觀察組治療后國際前列腺癥狀評分(IPSS)、儲尿期癥狀評分(USPSS)、排尿期癥狀評分(VSS)、膀胱過度活動癥評分(OABSS)(9.6±1.4)、(8.5±1.3)、(8.3±1.7)、(5.9±1.2)分均優(yōu)于對照組的(15.5±2.1)、(12.4±1.9)、(14.1±2.5)、(7.2±1.4)分, 差異均具有統(tǒng)計學(xué)意義(P<0.05)。觀察組治療后最大尿流率(Qmax)、平均尿流率(Qave)、尿量(UV)、殘余尿量(13.98±2.32)ml/s、(7.28±1.76)ml/s、(265.7±12.2)ml、(26.4±7.5)ml均優(yōu)于對照組的(11.69±
  1.47)ml/s、(5.87±2.01)ml/s、(223.5±13.4)ml、(38.2±8.1)ml, 差異均具有統(tǒng)計學(xué)意義(P<0.05)。兩組不良反應(yīng)發(fā)生率比較差異無統(tǒng)計學(xué)意義(P>0.05)。結(jié)論 坦索羅新單藥治療后加用索利那新對良性前列腺增生伴膀胱過度活動癥效果顯著, 利于排尿功能的改善, 癥狀緩解效果確切, 不良反應(yīng)可控, 具有積極的臨床意義。
  【關(guān)鍵詞】 良性前列腺增生;膀胱過度活動癥;坦索羅辛;索利那新;應(yīng)用價值
  DOI:10.14163/j.cnki.11-5547/r.2018.12.051
  【Abstract】 Objective To investigate the application value of tamsulosin and solifenacin for benign prostatic hyperplasia (BPH) complicated with overactive bladder (OAB). Methods A total of 120 patients with benign prostatic hyperplasia complicated with overactive bladder were randomly divided into control group and observation group, with 60 cases in each group. The control group was treated with tamsulosin, and the observation group was treated with tamsulosin and solifenacin. Comparison were made on symptoms improvement, changes in urodynamic parameters, and occurrence of adverse events between the two groups. Results After treatment, the observation group had better International Prostatic Symptom Score (IPSS), storage symptom score (USPSS), voiding symptoms score (VSS) and overactive bladder score (OABSS) as (9.6±1.4), (8.5±1.3), (8.3±1.7) and (5.9±1.2) points than (15.5±2.1), (12.4±1.9), (14.1±2.5) and (7.2±1.4) points, and the difference was statistically significant (P<0.05). After treatment, the observation group had maximum urine flow rate (Qmax), mean urine flow rate (Qave), urine volume (UV), residual urine volume as (13.98±2.32) ml/s, (7.28±1.76) ml/s, (265.7±12.2) ml and (26.4±7.5) ml than (11.69±1.47) ml/s, (5.87±2.01) ml/s, (223.5±13.4) ml and (38.2±
  8.1) ml in the control group, and their difference was statistically significant (P<0.05). Both groups had no statistically significant difference in incidence of adverse reactions (P>0.05). Conclusion Application of tamsulosin and solifenacin shows remarkable effect for benign prostatic hyperplasia complicated with overactive bladder. It is beneficial to improve voiding function with accurate symptomatic relief effect and controllable adverse reaction. It contains positive clinical significance.

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