[摘要]目的 探討藥物干預對晚期腫瘤合并抑郁狀態(tài)患者生活質量的影響。方法 選擇2012年4月～2016年4月在我院診斷治療的晚期腫瘤合并標準抑郁狀態(tài)的患者214例，采用隨機數字表法將其分為實驗組112例，對照組102例，對照組患者進行常規(guī)的抗腫瘤治療，實驗組在對照組治療基礎上，每日早、午飯后各予1片氟哌噻噸美利曲辛片治療，>60歲的患者每日早飯后服用1片氟哌噻噸美利曲辛片。1、2、3、4周后再次用QOL量表進行評分。結果 實驗組患者第4周后數值高于第0組，差異有統(tǒng)計學意義（P<0.05），實驗組患者治療后QOL評分高于對照組，差異均有統(tǒng)計學意義（P<0.05），實驗組的副作用高于對照組（P<0.05）。結論 晚期腫瘤合并抑郁狀態(tài)聯合應用氟哌噻噸美利曲辛藥物干預，可提高晚期腫瘤合并抑郁狀態(tài)患者的生活質量，無明顯不良反應，值得臨床應用。
　　[關鍵詞]晚期腫瘤；抑郁狀態(tài)；氟哌噻噸美利曲辛片
　　[中圖分類號] R732 [文獻標識碼] A [文章編號] 1674-4721（2018）2（b）-0080-03
　　Influence of drug intervention on the quality of life in patients with advanced tumor and depression
　　GAO Jin-suo WANG Jian-bing LIU Wei-wei YANG Jin-zhu
　　Department of Oncology，the Third People′s Hospital of Hefei City in Anhui Province，Hefei 230022，China
　　[Abstract]Objective To investigate the effect of drug intervention on quality of life in patients with advanced tumor and depression.Methods From April 2012 to April 2016，214 patients with advanced tumor complicated with standard depression were selected and randomly divided into experimental group（112 cases），control group（102 cases）and control group （102cases）.The patients in the experimental group were treated with conventional anti-tumor therapy.on the basis of the treatment of the control group，the patients in the experimental group were treated with one tablet of Flupentixol Melitracen every morning and one tablet of Flupentixol Melitracen every day after lunch，and the patients>60 years old were treated with 1 tablet of Flupentixol Melitracen every day after breakfast. After 1，2，3 and 4 weeks，QOL scale was used to score again.Results The QOL score of the experimental group at week 1-4 was significantly higher than that before treatment （P<0.05）.The QOL score of the experimental group was higher than that of the control group（P<0.05），and the side effect of the experimental group was higher than that of the control group （P<0.05）.Conclusion Drug intervention of Flupentixol Melitracen can improve QOL of patients with advanced tumor combined with depression，and without obvious adverse reactions，is worthy of clinical application.
　　[Key words]Advanced tumor；Depression；Flupentixol and Melitracen Tablets
　　目前的醫(yī)學模式是生物-心理-社會醫(yī)學模式 [1]。隨著醫(yī)學模式的轉變，生活質量（quality of life，QOL） 的概念漸漸引入醫(yī)學研究中[2]。近20 年來，QOL 己被廣泛應用于各種慢性病防治，特別是腫瘤患者治療效果的評價上，成為癌癥治療臨床試驗的終點之一[3]。晚期腫瘤患者合并抑郁癥比例高，危害患者的生活質量，嚴重的抑郁癥甚至是癌癥患者自殺傾向[4]。臨床醫(yī)師對晚期腫瘤合并抑郁癥的關注也較少。我們應用漢密爾頓抑郁量表（HRSD）及QOL量表，對晚期患者進行調查，對符合診斷標準的患者，選用氟哌噻噸美利曲辛片對晚期腫瘤患者合并有抑郁狀態(tài)患者進行藥物干預，觀察晚期患者生活質量的改變，現報道如下。

相關熱詞搜索：晚期 干預 生活質量 腫瘤 合并