[摘要] 目的 分析循環(huán)腹腔熱灌注化療（CHPPC）聯(lián)合靜脈化療對老年胃癌患者治療的臨床效果及對患者血清骨橋蛋白（OPN）、nm23H1蛋白表達的影響。 方法 選取2016年1月～2017年1月河北北方學院附屬第一醫(yī)院收治的80例老年胃癌患者，并采用隨機信封法分為觀察組和對照組，每組40例。對照組采用常規(guī)靜脈化療方案進行治療，觀察組采用CHPPC聯(lián)合靜脈化療方案進行治療，在治療結(jié)束8周后對治療短期效果進行評估，并比較兩組血清中癌胚抗原（CEA）、糖鏈抗原（CA242）、糖鏈抗原19-9（CA199）、OPN、nm23H1蛋白表達水平。 結(jié)果 治療后，觀察組治療總有效率顯著高于對照組，差異有高度統(tǒng)計學意義（P < 0.01）；治療后，兩組患者清中CEA、CA199及CA242水平均低于治療前（P < 0.05），且觀察組低于對照組（P < 0.05）；治療后，兩組患者血清中OPN水平低于治療前（P < 0.05），nm23H1蛋白表達水平高于治療前（P < 0.05），且觀察組血清中OPN水平低于對照組（P < 0.05），nm23H1蛋白表達水平高于對照組（P < 0.05）。 結(jié)論 老年胃癌患者采用CHPPC聯(lián)合靜脈化療方案治療后可有效提高臨床療效，并改善血清中OPN及nm23H1水平，具有廣泛臨床意義。
　　[關(guān)鍵詞] 循環(huán)腹腔熱灌注化療；靜脈化療；老年胃癌；骨橋蛋白；nm23H1
　　[中圖分類號] R735.2 [文獻標識碼] A [文章編號] 1673-7210（2018）02（c）-0171-04
　　[Abstract] Objective To analyze the effect of continuous hyperthermic peritoneal perfusion chemotherapy （CHPPC） combined with intravenous chemotherapy on the treatment of elderly patients with gastric cancer and the influence of expression of OPN and nm23H1 protein in the serum of the patients. Methods From January 2016 to January 2017， 80 elderly patients with gastric cancer in the First Affiliated Hospital of Hebei North University were selected， and divided into observation group and control group by random envelope method， with 40 cases in each group. The control group was treated with conventional intravenous chemotherapy， observation group was treated with CHPPC combined with intravenous chemotherapy， and the short-term efficacy of the treatment was evaluated 8 weeks after treatment， the serum CEA CA242， CA199， OPN， nm23H1 protein expression level between two groups were compared. Results After treatment， the total effective rate in observation group was higher than control group， the difference was highly statistically significant （P < 0.01）. After treatment， the serum CEA CA242， CA199 level of patients in both groups were lower than those before treatment （P < 0.05）， and observation group were lower than those control group （P < 0.05）. After treatment， the serum OPN level of patients in both groups was lower than before treatment （P < 0.05）， nm23H1 protein expression level was higher than before treatment （P < 0.05）， and the serum OPN level in the observation group was lower than control group （P < 0.05）， nm23H1 protein expression level was higher than control group （P < 0.05）. Conclusion Elderly patients with gastric cancer treated with CHPPC combined with intravenous chemotherapy can effectively improve the clinical efficacy and improve serum OPN and nm23H1 levels， and it has extensive clinical significance.

相關(guān)熱詞搜索：血清 胃癌 化療 靜脈 蛋白