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<br>　　[摘要]目的分析上消化道出血患者采用奧美拉唑治療對(duì)尿酸的影響。方法選取2015年10月～2017年3月我院收治的50例上消化道出血患者作為研究對(duì)象，通過自愿方式將其劃分為對(duì)照組和觀察組，每組各25例。對(duì)照組患者采用西咪替丁進(jìn)行治療，觀察組患者采用奧美拉唑進(jìn)行治療。觀察并記錄兩組患者不同時(shí)期的血清尿酸（SUA）值及血清尿素氮值，比較兩組患者不同出血量及癥狀的SUA值。結(jié)果兩組患者入院時(shí)SUA、出血時(shí)血清尿素氮值比較，差異無統(tǒng)計(jì)學(xué)意義（P>0.05）。觀察組患者出血停止2周后SUA明顯高于對(duì)照組，停止出血后血清尿素氮值明顯低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組出血量>1000 ml、出血量500～1000 ml患者的SUA比較，差異無統(tǒng)計(jì)學(xué)意義（P>0.05），觀察組的出血量<500 ml、休克癥狀、未休克患者的SUA均明顯低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論消化道出血患者采用奧美拉唑，一定程度上影響尿酸含量，促使尿酸趨于正常。<br>　　[關(guān)鍵詞]奧美拉唑；上消化道出血；尿酸<br>　　[中圖分類號(hào)] R573.2 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721（2018）2（b）-0123-03<br>　　Effect of Omeprazole on uric acid in patients with upper gastrointestinal bleeding<br>　　Liu Shi-jie Zhu Sheng-huang Xiao Feng-lian Liu Chun-mei Xia Jun-chao<br>　　Department of Gastroenterology，Ganzhou Municipal Hospital，Jiangxi Province，Ganzhou 341000，China<br>　　[Abstract]Objective To analyze the effect of Omeprazole on uric acid in patients with upper gastrointestinal bleeding.Methods 50 patients with upper gastrointestinal hemorrhage admitted in our hospital from October 2015 to March 2017 were selected as subjects and divided into control group and observation group by voluntary way，with 25 cases in each group.Patients in the control group were treated with Cimetidine and patients in the observation group were treated with Omeprazole.The serum uric acid （SUA） values and serum urea nitrogen values of the two groups of patients were observed and recorded，and SUA values of different blood loss and symptoms were compared between the two groups.Results There was no statistically significant difference in SUA values at admission and serum urea nitrogen when bleeding between the two groups （P>0.05）.The SUA in the observation group was significantly higher than that in the control group after 2 weeks of bleeding，and the serum urea nitrogen after the cessation of bleedingas significantly lower than that in the control group，and the differences were statistically significant （P<0.05）.The SUA of patients with the bleeding >1000 ml，the bleeding 500-1000 ml were compared between the two groups，and the differences were not statistically significant （P>0.05）.The SUA of patients with the bleeding <500 ml，had shock symptoms and not shock in the observation group were significantly lower than those in the control group，the differences were statistically significant （P<0.05）.Conclusion Omeprazole can affect uric acid to some extent，and promote uric acid to be normal.<br>　　[Key words]Omeprazole；Upper gastrointestinal bleeding；Uric acid<p style="margin-bottom:10px"><strong>相關(guān)熱詞搜索：</strong><a href="http://www.91mayou.com/tag/%C4%F2%CB%E1.html" target="_blank">尿酸</a> <a href="http://www.91mayou.com/tag/%CF%FB%BB%AF%B5%C0.html" target="_blank">消化道</a> <a href="http://www.91mayou.com/tag/%B3%F6%D1%AA.html" target="_blank">出血</a> <a href="http://www.91mayou.com/tag/%B0%C2%C3%C0.html" target="_blank">奧美</a> <a href="http://www.91mayou.com/tag/%BB%BC%D5%DF.html" target="_blank">患者</a> </p> <p><script type="text/javascript">ok3w_ads("s006");</script></p> <p><span id="zxxfnzaxv" class="disclaimer"><script type="text/javascript">ok3w_ads("s007");</script></span></p> <p><script type="text/javascript">ok3w_ads("s0013");</script></p></div> <div id="zxxfnzaxv" class="comments_list"></div></div> <div id="zxxfnzaxv" class="main_right"> <div id="zxxfnzaxv" class="adv_jietao"><script type="text/javascript">ok3w_ads("s008");</script><div class="zxxfnzaxv" id="baidu_clb_slot_230444"></div></div> <div id="zxxfnzaxv" class="det_comments"> <h3>熱點(diǎn)文章閱讀</h3> <ul> <li><a href="http://www.91mayou.com/meiwenzhaichao/1834.html" target="_blank" title="調(diào)教美文">調(diào)教美文</a> <span>2017-01-15</span></li> <li><a href="http://www.91mayou.com/meiwenzhaichao/251765.html" target="_blank" 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